Implications for prediction and regulatory assessment of biotransformation

The new insights gained on environmental, operational and microbial factors that govern biotransformation have the potential to significantly improve our ability to predict and assess contaminant biotransformation in a regulatory context. Under this topic we will explore how the new knowledge could be used to improve the accuracy of biotransformation predictions, and to what extent these insights have already been implemented into (quantitative) structure-biodegradation modeling and/or read-across approaches between contaminant biotransformation by microbial communities from different environments. This should also provide essential information to discuss new efficient strategies for biotransformation testing in a regulatory context and the feasibility of treating relative biodegradability across chemicals as an environment-independent, chemical-inherent property. The latter assumption forms the basis of persistence benchmarking, which is another proposition that has been made to simplify persistence assessment in a regulatory context.